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Proton Soup
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dgtech said:Cooking concentrates fats into longer chains which are harder to burn and temperature destroys vitamins. The link you posted actually supports most of the things I said and says nothing about synthesis in the human body.
If anything, it says "INGESTION" which means you eat it, not synthesize it
Humans can synthesize L-carnitine but can't acetylate it, that's what I've been taught at school and if if you have information suggesting otherwise, I'd be happy to fix that eventual educational mistake ;)
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ALCAR is an acetylated derivative of L-carnitine. During strenuous exercise, a large portion of L-carnitine and unused acetyl-CoA are converted to ALCAR inside mitochondria by carnitine O-acetyltransferase.[1]
you might also want to look up the meaning of the word endogenous
http://www.ncbi.nlm.nih.gov/pubmed/19720100
Adv Drug Deliv Rev. 2009 Nov 30;61(14):1332-42. Epub 2009 Aug 29.
Mitochondria in the elderly: Is acetylcarnitine a rejuvenator?
Rosca MG, Lemieux H, Hoppel CL.
Center for Mitochondrial Diseases and Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
Abstract
Endogenous acetylcarnitine is an indicator of acetyl-CoA synthesized by multiple metabolic pathways involving carbohydrates, amino acids, fatty acids, sterols, and ketone bodies, and utilized mainly by the tricarboxylic acid cycle. Acetylcarnitine supplementation has beneficial effects in elderly animals and humans, including restoration of mitochondrial content and function. These effects appear to be dose-dependent and occur even after short-term therapy. In order to set the stage for understanding the mechanism of action of acetylcarnitine, we review the metabolism and role of this compound. We suggest that acetylation of mitochondrial proteins leads to a specific increase in mitochondrial gene expression and mitochondrial protein synthesis. In the aged rat heart, this effect is translated to increased cytochrome b content, restoration of complex III activity, and oxidative phosphorylation, resulting in amelioration of the age-related mitochondrial defect.
PMID: 19720100 [PubMed - indexed for MEDLINE]