My textbook’s explanation for spontaneous renaturation of defolded protein is this: “Although in defolded state protein has grater entropy, greater degree of disorder, it folds into original conformation (lower entropy), and this seems to be in collision with the II law of thermodynamics. But by refolding molecules of water surrounding him increase its own entropy by forming maximum number of hydrogen bonds (they’re squeezing, pushing in hydrophobic regions from protein surface inside of protein, allowing hydrophilic regions to come out to surface to form H-bonds with water), so net change in entropy of solute and protein is than increase of entropy, and process is spontaneous.” Thing that I disagree in this that by forming hydrogen bonds water is increasing its own entropy, how can this be true ? By forming maximum number of (or generally forming) hydrogen bonds water increases its order, by organizing own molecules in ordered fashion dictated by hydrogen bonds. Than how can this H-bond forming could be S increasing? Please help. Regards.