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Biology and Medical
Can a Single Nucleotide Mutation Significantly Change a Protein's Function?
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[QUOTE="Ygggdrasil, post: 6152450, member: 124113"] Given the human genome size of ~ 3e9 base pairs and a mutation rate of 2.5e-8, we expect ~ 75 new mutations each generation. According to Wikipedia, modern Homo sapiens emerged about 250,000 years ago. Assuming a generation time of ~20 years, this corresponds to ~12,500 generations. Thus, each modern human should have ~ 1 million differences from the ancestral human genome (assuming no selection). Thus two random individuals might expect ~ 2 million differences between their genomes. Interestingly, studies have estimated that two individuals will typically have ~20 million differences between their genomes ([URL]https://en.wikipedia.org/wiki/Human_genetic_variation[/URL]), so that back of the envelope calculation above is somehow too low by an order of magnitude. [/QUOTE]
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Can a Single Nucleotide Mutation Significantly Change a Protein's Function?
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