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stevmg
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How can one transplant a (donor) tissue to a recipient allograft and have it "take" if the donor and recipient are of different sex? They are automatically genetically different which can never be broached.
stevmg said:How can one transplant a (donor) tissue to a recipient allograft and have it "take" if the donor and recipient are of different sex? They are automatically genetically different which can never be broached.
Student100 said:Quite easily, they do it like any other transplant.
There are associated risk factors: antibody development, increased mortality during female to male heart transplants, female to male liver transplants, etc, that aren't completely understood. I would guess to say that they prefer in sex transplants over male <> female transplants whenever possible.
stevmg said:Sounds like GVH disease would be more common in F > M transplant due to extra X and more potent immunologic response by female tissue and T-cells.
stevmg said:Works the other way. The tissue that does the reacting is the donor tissue (the female tissue.) Hence the F > M transplant will result in a greater reaction (GVH.)
Student100 said:Didn't know that, thanks.
Tissue transplantation is the process of replacing damaged or diseased tissue with healthy tissue from a donor. This can involve transplanting whole organs, such as a heart or kidney, or smaller sections of tissue, such as skin or bone.
Donor-recipient sex differences refer to the potential impact of the biological sex of the donor and recipient on the success and outcome of a tissue transplantation. This includes differences in immune response, hormone levels, and genetic factors.
Donor-recipient sex differences can affect tissue transplantation in several ways. For example, a male-to-female transplant may have a higher risk of rejection due to differences in immune response. Additionally, certain hormones and genetic factors may also play a role in the success of the transplant.
Yes, certain tissues may be more affected by donor-recipient sex differences than others. For example, studies have shown that heart and kidney transplants have higher success rates when the donor and recipient have the same biological sex. However, more research is needed to fully understand the impact of sex differences on various types of tissue transplants.
To minimize the impact of donor-recipient sex differences on tissue transplantation, it is important to carefully match donors and recipients based on factors such as biological sex, blood type, and tissue compatibility. Additionally, ongoing research and advancements in medical technology may help improve the success rates of tissue transplants regardless of donor-recipient sex differences.