# Tomorrow I will make ~$70,000 in 8 hours. gravenewworld MY DRUG GOT APPROVED BY THE FDA AND IT IS THE FIRST DRUG OF ITS KIND! http://biz.yahoo.com/bw/080520/20080520006603.html?.v=1 I've got at least 10,000 shares at$3.00. My stock should reach the $8-10 range tomorrow when the market opens. We've got a ton of other good crap in our pipeline, I could become filthy rich from just working here. ## Answers and Replies rewebster MY DRUG GOT APPROVED BY THE FDA AND IT IS THE FIRST DRUG OF ITS KIND! http://biz.yahoo.com/bw/080520/20080520006603.html?.v=1 I've got at least 10,000 shares at$3.00. My stock should reach the $8-10 range tomorrow when the market opens. We've got a ton of other good crap in our pipeline, I could become filthy rich from just working here. Good--great--- --and, I'm glad you're not working on bad crap Staff Emeritus Science Advisor Gold Member Congrats! moose That's exciting. I'm really happy because I might make 25,000 over the next 4 months... makethings Is it really possible for the stock to increase 200% on just this one drug ? I mean is it really something many people are suffering from bowel reconstruction? If it were a cancer drug I would believe it but i guess we'll have to wait and see. congrats on the windfall Cyrus So, does this mean I should buy a whole bunch? Are you sure you can announce this? waht Nice. You guys must have a good hunch or something. rewebster So, does this mean I should buy a whole bunch? Are you sure you can announce this? its a press announcement hypatia The press release is already posted, so its ok for him to mention it. By the way, good job! Mentor Good luck GNW! Staff Emeritus Science Advisor Gold Member Congrats! Though, I'm a bit confused. I thought that was the drug you were talking about a while ago that was running into major side effects in clinical trials and facing discontinuation. Or was it something similar in name/function, but not this one? Admin 16%+ in after market, looks like it will be a good day for you tomorrow! Next time tell us the day before the PR... JK! :) Last edited: Staff Emeritus Science Advisor Gold Member 16%+ in after market, looks like it will be a good day for you tomorrow! Next time tell us the day before the PR... JK! :) Should we start calling you Martha? :rofl: Admin I could become filthy rich from just working here. btw, you should donate some of that to charit... Physics Forums :) Staff Emeritus Science Advisor Congrats gnw. Don't go crazy spending it now. Certainly that could be useful for paying off school loans. Hopefully this will boost the companies revenues and provide some breathing room for the near term. gravenewworld Congrats! Though, I'm a bit confused. I thought that was the drug you were talking about a while ago that was running into major side effects in clinical trials and facing discontinuation. Or was it something similar in name/function, but not this one? Ha, it is the same drug indeed. So far, it is approved for short term use after post operative ileus surgery. The complications we have ran into were for long term usage of the drug to treat opioid bowel disfunction (OBD) which comes from the long term use of opioid analgesics for chronic pain. The FDA put a clinical hold against us for clinical trials in OBD, but after today the FDA lifted its hold and research will continue. This is why I think the stock will nearly double. The OBD market is much bigger and probably worth at least a billion dollars or more. If you look at the data from the last clinical trial for OBD all of the negative incidents came from only 1 research site. Why? Research will continue. Right now we also have a 2 delta opioid agonists in phase II right now. The delta compounds are the first opioid pain killers out there to target the delta receptor. If that shows good data too, the sky is the limit since we have even more good stuff in our pipeline. http://sec.edgar-online.com/2007/12/05/0001193125-07-259725/Section10.asp [Broken] FYI---if you are not familiar with opioids, opioids are some of the most potent analgesics known. There are 3 main opioid receptors: mu, kappa, and delta. Drugs like morphine target the mu receptor. Our 2 compounds in phase II target the delta, which no drug out there right now does. Last edited by a moderator: z-component Congratulations! You work in Exton? gravenewworld Congratulations! You work in Exton? Yeah. Staff Emeritus Science Advisor Gold Member Ha, it is the same drug indeed. So far, it is approved for short term use after post operative ileus surgery. The complications we have ran into were for long term usage of the drug to treat opioid bowel disfunction (OBD) which comes from the long term use of opioid analgesics for chronic pain. The FDA put a clinical hold against us for clinical trials in OBD, but after today the FDA lifted its hold and research will continue. This is why I think the stock will nearly double. The OBD market is much bigger and probably worth at least a billion dollars or more. If you look at the data from the last clinical trial for OBD all of the negative incidents came from only 1 research site. Why? Research will continue. Right now we also have a 2 delta opioid agonists in phase II right now. The delta compounds are the first opioid pain killers out there to target the delta receptor. If that shows good data too, the sky is the limit since we have even more good stuff in our pipeline. http://sec.edgar-online.com/2007/12/05/0001193125-07-259725/Section10.asp [Broken] FYI---if you are not familiar with opioids, opioids are some of the most potent analgesics known. There are 3 main opioid receptors: mu, kappa, and delta. Drugs like morphine target the mu receptor. Our 2 compounds in phase II target the delta, which no drug out there right now does. Ah, cool. If you develop one specific for the kappa receptor, let me know! We're interested in that one in controlling reproductive cycles. Last edited by a moderator: gravenewworld Ah, cool. If you develop one specific for the kappa receptor, let me know! We're interested in that one in controlling reproductive cycles. Actually you know what? I think we already have explored the kappa receptor. The program was started and axed before I even got there (for reasons I do not know). I'm sure if I look through our compound library I will find some potent kappa agonists/antagonists that we have previously made. The program could have been terminated due to toxicity issues or maybe for the simple fact that we didn't see any in vivo efficacy in pain models. But who knows, maybe they would work in another model for a different treatment. Admin Looks like you'll have to wait a bit longer for that big reward gnw! :( rewebster Looks like you'll have to wait a bit longer for that big reward gnw! :( yep... I had a feeling it wasn't going to be the big growth item like Viagra Mentor Yeah. Hey, I live in Collegeville (right near GSK). I'm working on a project in Exton right now - on Lancaster Ave. Admin the market is just getting murdered lately. I am aching to get to the sidelines. I'm down 8% today. Jimmy Snyder I had a feeling it wasn't going to be the big growth item like Viagra. :rofl: Sorry, it didn't last more than 4 hours. You did well to get this at$3, it had been as high as $29 at one time. gravenewworld Looks like you'll have to wait a bit longer for that big reward gnw! :( Dang. There is a lot of speculation out there, after FDA approval, why has the stock actually gone down? Many think that the stock is being artifically kept low (which is probably illegal though) so a big firm like GSK can buy us out for much cheaper. Maybe they will give me a 2 year salary severance package, that would be sweet if got that and found a new job right away. rewebster Dang. There is a lot of speculation out there, after FDA approval, why has the stock actually gone down? Many think that the stock is being artifically kept low (which is probably illegal though) so a big firm like GSK can buy us out for much cheaper. Maybe they will give me a 2 year salary severance package, that would be sweet if got that and found a new job right away. ---you've got another couple drugs in the oven, right? gravenewworld ---you've got another couple drugs in the oven, right? Yeah we have a lot of good stuff going on in R&D right now which I can't discuss and good stuff in the pipeline. That is why a lot of people think we are a huge target for a buy out by a big firm. The company was founded by venture captalists, so if the opportunity comes to make a ton of lucre in a quick manner I'm sure they wouldn't hesitate at all to sell. Sorry, it didn't last more than 4 hours. You did well to get this at$3, it had been as high as $29 at one time. Yeah I was here when it was at$29. That was back when our drug had implications for OBD, which is projected to be a billion dollar market. The FDA put us on clinical hold for trials for that indication, but we have a really good shot now at getting that hold lifted.

Staff Emeritus
Gold Member
Actually you know what? I think we already have explored the kappa receptor. The program was started and axed before I even got there (for reasons I do not know). I'm sure if I look through our compound library I will find some potent kappa agonists/antagonists that we have previously made. The program could have been terminated due to toxicity issues or maybe for the simple fact that we didn't see any in vivo efficacy in pain models. But who knows, maybe they would work in another model for a different treatment.

I'm not interested in them for pain models, so if you find that they aren't toxic and really are specific (and preferably are soluble in aqueous solution), shoot me a PM if there's any chance some could be parted with,and I'll promptly get in touch with my collaborators who really would love a specific kappa antagonist (we can certainly do the whole non-disclosure agreement thing regarding the compound itself, if this is even a possibility).

sysreset
Gravenewworld, I think the problem is that this drug was originally intended for the OBD population, which takes meds orally, and this is an oral drug. When that bombed, it was re-targeted to the post-op ileus population. Problem is, it is still an oral drug, and the target population is "NPO" - meaning, they need an IV solution...

gravenewworld
Gravenewworld, I think the problem is that this drug was originally intended for the OBD population, which takes meds orally, and this is an oral drug. When that bombed, it was re-targeted to the post-op ileus population. Problem is, it is still an oral drug, and the target population is "NPO" - meaning, they need an IV solution...

The drug was originally designed for both POI and OBD at the same time. I don't believe that after bowel surgery patients are restricted ONLY to IV treatment. After bowel surgery, doctors are going to try to get their patients on a solid diet as fast as possible. If a patient can eat solid food, they can take the drug. In the clinical trials for POI, patients were given pills. If the patients really needed an IV formulation, then the drug would have never gotten through for PO use.

binzing
When I saw the OP I thought he must be a high class male prostitute or something. (DC Miestro anyone?)

gravenewworld
When I saw the OP I thought he must be a high class male prostitute or something. (DC Miestro anyone?)

I wish I was, I wish I was... (or is it were?)