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Tylenol and Advil

  1. Jan 16, 2005 #1
    For a school project, i have to research production of Tylenol and Advil - but i can't find ANYTHING!!!

    - What reactions are involved when producing acetaminophen and ibuprofen?
    - What factors affect production of these products?
     
  2. jcsd
  3. Jan 16, 2005 #2

    chem_tr

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    Tylenol is a commercial drug, which has the main ingredient, acetaminophen aka paracetamol. Ibuprofen is, 2-(p-isobutylphenyl)propionic acid. I found the data on this website. Advil is the second commercial drug, with ibuprofen in it as the main ingredient.

    So you are looking a way for their synthesis, right?
     
  4. Jan 16, 2005 #3
    Actually, i found out that acetaminophen is the synthesis of acetic anhydride and p-aminophenol. But i'm not sure how ibuprofen can be synthesized. Any ideas?
     
  5. Jan 16, 2005 #4

    chem_tr

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    I have found this, a Friedel-Crafts reaction with acetyl chloride on alkyl benzene at 4-position, then a mystery-two-step reaction for a keto group to convert it into an aldehyde, preparation of an oxime from it, and synthesis of a nitrile from this one was used. The nitrile is hydrolyzed to give the desired product, the carboxylic acid. This is a cue for you, although this is not a cue anymore :wink:
     
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