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Understanding 23andme results

  1. Mar 3, 2015 #1
    For anyone that doesn't know, 23andme is a company that sequences your genome for you (you send them a saliva sample). It gives you a raw data file ful of SNPs. Heres an example of some SNPs from a raw data file:

    rs3128126 1 962210 GG
    rs2710875 1 977780 TT
    rs2465136 1 990417 CT
    rs2488991 1 994391 --
    rs7526076 1 998395 AA
    rs3934834 1 1005806 CC
    rs3766192 1 1017197 CC
    rs3766191 1 1017587 CC
    rs9442372 1 1018704 AA
    rs10907177 1 1021346 AA
    rs3737728 1 1021415 AA
    rs10907178 1 1021583 AA
    rs11260588 1 1021658 GG
    rs9442398 1 1021695 --

    I have a few questions about this. Firstly, what does -- mean, does that mean the genotype of that SNP is unknown? Secondly, some SNPs only give one letter, what does that mean? Does that mean they could only determine the genotype of one of the alleles?
  2. jcsd
  3. Mar 4, 2015 #2
    The test cannot determine all SNPs with 100% accuracy. At some random positions the reading is incorrect or it is not readable at all. In the latter case the SNP is simply not reported. On the other hand, if a wrong reading has been made, you will never know it, unless you repeat the measurements several times.
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