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http://www.newscientist.com/news/news.jsp?id=ns99994318A scientist funded by the US government has deliberately created an extremely deadly form of mousepox, a relative of the smallpox virus, through genetic engineering.
The new virus kills all mice even if they have been given antiviral drugs as well as a vaccine that would normally protect them.
The work has not stopped there. The cowpox virus, which infects a range of animals including humans, has been genetically altered in a similar way.