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Vasoconstriction in Hemostasis

  1. Jul 25, 2004 #1
    In hemostasis there is an initial vasoconstriction as a result of a nervous reflex. This lasts less than one minute. However, vasoconstriction still occurs during coagulation as a result of released chemicals, eg - serotonin released in the platelet granuales. Now, there are two ways that chemical such as serotonin could lead to vasoconstriction and I was just wondering if anyone could tell me which one it is.
    Does release of serotonin:
    1) Lead to a nervous response which leads to vasoconstriction (as nerves are usually the cause of muscular contraction), or
    2) Directly cause vasoconstriction, rather than it being a nervous response?
    I have my own idea as to which one I believe it is, but does anybody actually know?
    Thanks in advance. :-)
  2. jcsd
  3. Aug 5, 2004 #2
    Go on - somebody must know. :wink: Basically, all I want to know is whether the vasoconstriction in haemostasis is purely due to the chemicals released (eg - serotin) or the chemicals initiating a nervous response which causes vasoconstriction.
  4. Aug 7, 2004 #3
    Well I'll take a guess and say it's a related directly to intercellular serotonin concentration since SRIs have been demonstration to create vasoconstriction.
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