"In chemical signaling, adaptation enables cells to respond to changes in the concentration of a signaling ligand (rather than to the absolute concentration of the ligand) over a very wide range of ligand concentrations. The general principle is one of a negative feedback that operates with a delay. A strong response modifies the machinery for making that response, such that the machinery resets itself to an off position. Owing to the delay, however, a sudden change in the stimulus is able to make itself felt strongly for a short period before the negative feedback has time to kick in." -Molecular cell biology ,bruce albert I don't understand this paragraph. can anyone clarify this ( best with example , even paraphrasing it may help) .... I have also searched the net, for negative feedback that operate in delay.... got nothing helpful. Any help will be highly appreciated.