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What is the difference between proteasome and immunoproteasome?

  1. Apr 28, 2004 #1
    What is the difference between proteasome and immunoproteasome ??
     
  2. jcsd
  3. Apr 28, 2004 #2

    iansmith

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  4. Apr 28, 2004 #3

    iansmith

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    In case you don't get access to the journal

    A proteasome is an ATP-dependent, multi-subunit protease that plays the central role in intracellular protein degradation and once protein substrates have been degraded, the resulting peptide fragments are translocated from the cytoplasm to the endoplasmic reticulum and then loaded onto major histocompatibility complex (MHC) class I molecules. Proteasome is expressed in healthy, normal tissues and in immune-privileged organs such as the brain.

    An immunoproteasome is expressed in cells stimulated by gamma interferon (IFN-) or tumor necrosis factor alpha (TNF-), and in primary and secondary lymphoid organs. During an antiviral or antibacterial immune response, immunoproteasomes largely replace constitutive proteasomes. This replacement has a positive effect on MHC class I restricted antigen presentation.
     
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