But gene editing is possible today right? we have things like CRISPR gene editing and prime editing that can actually change our genome and CRISPR is even being tried on people in clinical trials to remove mutations from the body. Can CRISPR replace genes or just fix single mutations?.
it was one of my questions, but the main question was about fixing mutations(the damage they cause) by using gene replacement which is according to sciencedirect website: "Gene replacement therapy is the technique of recognizing a faulty gene, applying a piece of DNA in its correct form though a...
But what with all the studies about gene editing? there are many studies about in-vitro and in-vivo cases of gene editing and there are even approved drugs that deliver new genes to cells like Zolgensma. so what do you mean when you say "The only way to get new DNA in a cell is to replace that...
I not sure I understand your answer, why the brain should be off limits?. can't we replace or provide genes to an existing cells in the body without getting them out?.
I don't talk about what is possible right now but what is possible and practical using gene replacement therapy with delivery...
Recently I asked if prime editing can be used to reverse the random mutations we accumulate with aging(https://www.physicsforums.com/threads/can-prime-editing-fix-every-harmful-mutation-in-all-our-cells.1003279/) but now I have a different question. Can we simply replace our genes to get rid of...
I found this part of some article about Prime Editing: https://www.researchgate.net/figure/Validation-of-PE2-off-target-sites-identified-by-Cas9-H840A-nickase-mediated_fig3_344307018
I see that there is data about "relative frequency(off-target activity/on-target activity)" what does it means...
It seems like some articles suggest that prime editing(or one version of if) can actually have low enough off-target levels.
https://www.nature.com/articles/s41434-021-00263-9
"The absence of DSB formation promises to impart a significant layer of safety to PE-based therapies. Critically, in two...
How can current gene editing technologies like Prime Editing can be used to reverse all age related mutations that negatively affect some type of cell like neurons?. According to this article (you need to click on the "toggle reader view" button in firefox in order to read it without registering...
Is this the main reason for why gene editing treatments have a problem to "scale up" with repeated treatments?. There is a research about a way to overcome this problem?. There is a way to prevent the immune response to the particular virus?.
About the highly reflective surface thing, from what I understood different materials have different reflectivity in different wavelengths and some of the laser weapons are actually several laser beams focused into one spot(this what I read about the Israeli laser weapon) so can't the laser...
so the same goes to prime editing and other genome editing methods?. what prevent prime editing or other genome editing method like CRISPR from fixing every harmful mutation in the body?.
So Zolgensma only works in 41 percent of the patients because it manage to change the DNA of cells in only small part of the neurons in the spine and brainstem?. If the treatment will repeat several times does it mean that the drug will replace the SMN gene in more neurons?.
Actually from what I read(like the article in my original post) pulsed laser is different in that it cause ablation of the surface and this have a kinetic impact that is actually used to punch holes into steel and is even able to propel things in Ablative laser propulsion. Pulsed laser even have...
It looks like we are already going to have lasers capable of destroying cruise missiles by 2022 https://breakingdefense.com/2019/12/exclusive-three-ways-to-kill-cruise-missiles-pentagon-to-test-rival-lasers/
Israel also announced a breakthrough in laser technology last year...