This is not representative of the flu level in the UK over the years. If, fact in this very article you quote it says its at least double the level of what it should normally be. So is this the typical level in the US or was there an epidemic? Because the UK would then typically have have half...
But this is not representative of the typical flu level over the years. If it were an experiment, the 2017-2018 level you are quoting and matching with the US would be a far outlier for the UK. Is 27 per 100,000, the typical level?
Why do so many people in the US get the flu? In Europe, we might have a flu vaccine once every 5 years or so ( at least in the UK and Ireland) and the flu level is very low to non-existant and almost never causes death. I'm wondering if there is a genetic component, Americans are more...
So , I don't think anyone actually answered your question. The mechanism of thermogenesis is associated with mitochondria. In the oxidative phosphorylation system, the electron flow from an oxidised NADH through complexes I-V to generate ATP is coupled to proton pumping from across the...
So an old-style easy way to check your accuracy with any pipette is with water. The scientific system of weight is based on the weight of water. So 1 gramme = 1 ml of water.
All you need is some light tissue paper. Put it on a balance and zero it, and pipette, let's say 1 ml of water onto the...
I wouldn't discuss the outline of this online for the sake of a forum discussion until its published either, since I want to get the credit. But thanks Bill.
This is actually my current research right now. We created drugs that essentially hit all the same pathways as caloric restriction . So I am probably one of maybe 10 people in the world that know how to stay young forever because I understand the biological mechanisms involved. I am uncovering...
Well that's not completely true. There was one other reported clinical case of paternal mitochondrial transmission made years before this study. So it wasn't the first time it was seen. However it must be so rare that no other clinical cases have been reported until now.
There were also...
Because the first two bases are necessary to specify the type of amino acid to be encoded. And they are both the same base. It wouldn't be silent if it was one of the first two bases because then it would be deleterious. Only the third base can change and you can still encode the same amino acid.
I wouldn't worry about it. The amyloid beta hypothesis of alzheimers disease is no longer convincing. All clinical trials to clear it from the brain resulted in clinical failure. There have been cases where patients have amyloid buildup with no clinical symptoms of alzheimers. The build-up of...
Yes, I did this experiment 10 years ago in neurons. You see the diffusion of photoactivatable GFP through the mitochondrial network as a proxy for the rate of fusion. But if you read the paper, in order to get into the matrix, the GFP will be unconjugated, it will no longer be bound to COX8...
They are trafficked to the mitochondrion, however as far as I know these tags are not able to incorporate into the matrix for instance. When you attach a GFP to let's say, a subunit of the oxidative phosphorylation system with a mitochondrial targeting sequence, the GFP is targeted to...
So the different parts 'supercomplexes' appear to assemble at different times. Some supercomplexes have been shown through pulse-chase to assemble as soon as 0.5 hrs but others do not assemble for many hours later. So it will be on the order of hours.
The tools for investigating this question...
So I do have access to super-resolution microscopy, we used super-resolution and 3D electron microscopy to discover the existence of mitochondrial nanotunnels, however the main issue would be penetrating the double membrane of the mitochondria. I think dendra-2 may be too large to get inside...