Recent content by Les Tete

@Yggdrasil I think you're wrong there. There are various methods developed in very recent times which have been shown to increase the fidelity of cleavage. I covered a lot of them, plus potential developments for the future when I was carrying out a risk assessment of whether Cas9 is safe to use...

@Yggdrassil They've tried to implant CCR5delta32 HSPCs (hematopoietic stem progenitor cells) in the past, but they are swiftly outcompeted by unmodified cells - or so the paper I've read says (below). http://www.pnas.org/content/111/26/9591.full @entropy1 You can simply design DNA sequences on...

This is really annoying. You do something like this, which at first glance appears to flout the policy agreements in place to not edit the human germline. You get people worked up, the researchers put something in like "it caused unintended mutations in the embryos", and it sounds even worse. Of...