Recent content by Planobilly
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Electrostatic scaling exponents vary across protein families
Hi Bill N is the number of atoms in each protein. Thank you for responding to this request. Bill, I am an old guy who has outlived all the people I have worked with, so I have a limited circle of friends left to talk to and ask these sorts of questions. Thanks again. Cheers, Billy- Planobilly
- Post #10
- Forum: Biology and Medical
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Electrostatic scaling exponents vary across protein families
Hi berkeman, Thanks for reopening the thread. I wasn't ignoring the question — I thought the thread was closed and didn't realize it had been reopened until now. Every equation in the pipeline comes from published, peer-reviewed sources. Nothing is original or speculative. Here are the...- Planobilly
- Post #9
- Forum: Biology and Medical
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Is A.I. more than the sum of its parts?
Hi Roberto, I'm very interested in what you proposed about designing tests to produce empirical evidence. All the empirical evidence I've collected from over a year of daily operational use tells me the answer to the OP's question is no: AI is not more than the sum of its parts. The truth is...- Planobilly
- Post #533
- Forum: Programming and Computer Science
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Is A.I. more than the sum of its parts?
Hi javisot, I'd agree with you if a machine could hallucinate — but it can't. Hallucination means perceiving something that isn't there. It requires subjective experience, a mind that is aware of what it's perceiving. LLM models have no awareness, no perception, no internal experience. They...- Planobilly
- Post #527
- Forum: Programming and Computer Science
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Is A.I. more than the sum of its parts?
Is A.I. more than the sum of its parts? I will respond to the original question based on my experience with AI. First, I am not a computer professional in the sense that I went to a university and got a related degree. I have worked in IT and was responsible for a 150,000-node network, so I do...- Planobilly
- Post #522
- Forum: Programming and Computer Science
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Electrostatic scaling exponents vary across protein families
Thanks for the feedback. I'm not sure this qualifies as a personal theory. This is a computational result — I ran all 550,122 proteins in the AlphaFold/SwissProt database through an electrostatics pipeline using standard AMBER ff14SB partial charges and reported what the numbers showed. That's...- Planobilly
- Post #4
- Forum: Biology and Medical
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Is A.I. more than the sum of its parts?
Hi jovisot That's a genuinely good question, and the answer is probably no. Hallucination isn't a bug — it's a byproduct of how the system generates text. The same mechanism that lets it generalize and produce novel responses is the same mechanism that produces confident nonsense. You can reduce...- Planobilly
- Post #435
- Forum: Programming and Computer Science
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Is A.I. more than the sum of its parts?
Hi You're asking the right question, but the answer is structural, not technical. The reason AI isn't optimized for correctness is economics, not capability. Being correct requires verification — checking claims against sources, running calculations, admitting uncertainty. All of that costs...- Planobilly
- Post #432
- Forum: Programming and Computer Science
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Is A.I. more than the sum of its parts?
I've been reading this thread with interest but haven't posted because until recently I didn't have the operational experience to say anything worth hearing. Now I do. I'm 78, retired, physics and engineering background, several patents. I run a small private AI lab out of my home in Florida —...- Planobilly
- Post #430
- Forum: Programming and Computer Science
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Electrostatic scaling exponents vary across protein families
I'll be checking back for responses and happy to answer questions or provide additional data. Fair warning — Wednesday morning I'm getting on my boat and heading to the Bahamas for four or five days, so if I'm slow to reply after that, I'm not ignoring you. You're welcome to come along, either...- Planobilly
- Post #2
- Forum: Biology and Medical
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Electrostatic scaling exponents vary across protein families
I want to be upfront: I don't have academic credentials in biology or bioinformatics. My background is in physics and engineering — I hold several patents and spent my career solving applied problems. I'm 78 years old, retired, and I run a small private AI lab out of my home in Florida purely...- Planobilly
- Thread
- alphafold Bioinformatics Electrostatics protein structure proteomics
- Replies: 9
- Forum: Biology and Medical
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Virtual Doctor's Visits - Do/Would You Use Them?
Way before the advent of the internet, calling a doctor or having a doctor call was common place. The ability for the doctor to visually see someone over the internet does not add very much in my opinion. For many things good medical triage can be done using telemedicine. It has it's uses. It...- Planobilly
- Post #5
- Forum: Biology and Medical
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COVID What impact has the COVID-19 pandemic had on your job?
I own a couple of agricultural businesses. My business has done exceptionally well in 2020 even with all the issues. There have been issues of delays in parts for machines. I have been exposed to Covid-19 by my employees but remain well. . I have been impacted by employee’s illness with...- Planobilly
- Post #142
- Forum: Biology and Medical
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COVID Medical Science, Medical Ethics, COVID-19
I guess we here on this forum are generally most interested in the understanding of the technical details of the virus. Being in my seventies and with some adverse health conditions, how all this works is pretty important to me. I own an agribusiness so I have several hazmat conditions to deal...- Planobilly
- Post #14
- Forum: Biology and Medical
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COVID Medical Science, Medical Ethics, COVID-19
"As a doctor or a scientist, it is unethical to send people (even enthusiastic, well-informed volunteers) into harm's way for the greater good. " So was it unethical to send me to Vietnam for two years or send someone to a more popular war? I like many vets would gladly give my life for the...- Planobilly
- Post #4
- Forum: Biology and Medical