Quote by The_Thinker
so... hmmm... if it is just a mathematical principle... then how is it that people use it as a fundamental principle? I have read and heard of things where they say that the HUP also applies to energy and that is why QM states that a pair of protons and antiprotons can just appear and annihilate each other stating HUP as a reason...
Have I heard or read wrong??

No, you have heard correctly. Unfortunatly, I don't have time for a full explanation now (I've got spiderman 3 tickets
). However, I can say that it isn't just a mathematical principle, it is the fundemental principle that the whole of QM is based on. It is if you like, the basis of the mathematical formalism behind QM.