I made the following conjecture

dodo

Post #9 shows examples of primes not of the form p + 2^n. I imagine that finding counterexamples for p - 2^n (in particular, checking those on A065381) is harder, since there is no limit to p or 2^n.

dodo	Post #9 shows examples of primes not of the form p + 2^n. I imagine that finding counterexamples for p - 2^n (in particular, checking those on A065381) is harder, since there is no limit to p or 2^n.