In a room with an open window and a fan, the air pressure inside the room will equalize with the outside air if the window is open before the fan is turned on. If the room is sealed, running a fan does not create additional pressure; it merely circulates air. When the fan is on in a sealed room, there is no meaningful pressure differential created, making it ineffective for building pressure. The discussion also highlights that household fans cannot create significant pressure differences, which is important for understanding airflow dynamics. Ultimately, the effectiveness of airflow management depends on the room's sealing and the fan's characteristics.