Hmmm. I think the fluid would flow faster down the middle of the column due to the resistance at the sides. (Duh!) And therefore, wouldn't a short fat column be more likely to allow accumulation of contaminants at the top and bottom edges where the caps contact the cylinder - since the flow...
Thank you Andy. Darcy's Law seems to explain that the total discharge (flow rate) is proportional to the permeability, cross-sectional area, viscosity and pressure drop, and inversely proportional to the length of the column, which all makes sense to me. But I guess I'm looking for some law of...
If you had to prove that your method for cleaning chromatography columns works and you had different sizes and shapes of columns, which one would you pick as a worst case to focus on? You have tall, skinny columns and short, fat columns, as well as different sizes. These are cylindrical glass...