ALS Research

[nautica]

I am doing some research on ALS. Do any of you have any links on peer reviewed journals or articles.

Thanks
nautica

[nautica]

^

[adrenaline]

here is a summary of the major clinical trials...but you may be looking for more bench research data that others may be able to help you with.

http://www.medscape.com/viewarticle/421564

Clinical trials in amyotrophic lateral sclerosis (ALS) have been conducted for over half a century now and have incorporated a wide variety of drugs. Most of these trials have had negative results and a cure remains elusive. The explosion in our understanding of molecular biology and parallel developments in clinical epidemiology have opened up a vast number of novel therapeutic strategies. However, advances in statistical analysis, computing, and global communications have also put greater pressure on scientific investigators to improve the design and implementation of clinical trials so that they permit rigorous testing of hypotheses within a solid ethical framework. This article documents the first published trial for all drugs tried clinically in the treatment of ALS, focusing in more detail on the large, multicenter trials of recent years, namely those involving riluzole, ciliary neurotrophic factor, insulin-like growth factor-I, brain-derived neurotrophic factor, and SR57746A. The problems in the design of trials in ALS are discussed, including the selection of end points and surrogate markers of disease progression, and the major parameters in ALS assessment are reviewed.........

[Tsu]

If you want real technical stuff, the Journal of the American Medical Association (JAMA) has a website (jama.com). You must register to access their archives but there are 184 articles to choose from with a quick search on ALS.

[nautica]

Nice, I appreciate it.

Nautica

[Monique]

Originally posted by nautica
I am doing some research on ALS. Do any of you have any links on peer reviewed journals or articles.

Thanks
nautica You must be familiar with PubMed right? (part of the National Library of Medicine) www.ncbi.nlm.nih.gov/PubMed/

Just type in what you are looking for, if you are not familiar I can give you some tips, such as:

[TA] is title abbreviation, if you write
jama [TA] and another keyword it will only find articles appearing in that journal

[DP] date publication, such as 2004 for the latest articles

[AU] author name such as "smith jk" [AU]

[TI] finds the keyword in the title

There are many more, you can also use Mesh terms [MH] which are catagorized keywords that will make your search very specific. There is a help file on the page that lists them all.

Assuming you are not familiar with Pubmed, there are links directly to the articles. If you are accessing the site through an academic institution, you will be able to easy access most of the articles (depending on the institution's subscription). Some journals are open access.