Chemokines....

[karthik3k]

What are the diseases realated to chemokines ??
I couldnt find anything about it on KEGG database!!!

[iansmith]

If you can get access to the following article, it migth answer some of your question

Chemokines and Alzheimer's disease (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11754998&dopt=Abstract)
Chemokines in Inflammatory Bowel Disease (http://www.biomedcentral.com/1529-7322/4/83/abstract)
Chemokines and disease (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?holding=npg&cmd=Retrieve&db=PubMed&list_uids=11175802&dopt=Abstract)
Cytokines and Chemokines in Autoimmune Disease: An Overview (http://www.eurekah.com/abstract.php?chapid=430&bookid=22&catid=7)
CXC-chemokines in coronary artery disease (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12871498&dopt=Abstract&holding=f1000)

[karthik3k]

Actually i got to design a project.
Since iam interested in Chemokines...
I wanted to do something like....
Docking chemokine...with ....
and running a MD (with AMBER/GROMACS) to check the Energy profiles ??? of all clusters ..


Any idea How and what to start with ??

[iansmith]

You should check the following paper

Structure Modeling of the chemokine Receptor CCR5: Implication of Ligand Binding and Selectivity (http://www.biophysj.org/cgi/content/full/83/6/3012)

this paper should help you getting started

[karthik3k]

Thanks
I got only single paper from that journal. But thats a good start.
Where can i get about the information in metabolic pathways?
I couldnt find Chemokines in KEGG or may be i didnt know where to find in that.