Intracellular Mechanism of IGF-1

[nautica]

IGF-1 has been shown to increase regeneration of nerve cells. I have seen the studies, but am unable to find the actual mechanisms. Does anybody have any information on this or know where I could find it.

I have look through my cell and molecular biology book, but can not seem to find it.

thanks
nautica

[Moonbear]

I doubt you'll find anything in a textbook on it. I don't think the mechanism is fully understood yet. Most of what I find on the topic seems to still be on a pretty basic level: add IGF-1 and see an effect on neuroprotection. If you do a pubmed search on "IGF-1 and neurons" you'll get a long list of results. I only skimmed a few pages in and saw a few titles suggesting the PI3 kinase pathway may be involved, but nothing more than that.

[nautica]

Yup, thats what I was afraid of.

Thanks for your thoughts.
Nautica