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-   -   Spontaneous drug release rate equation (http://www.physicsforums.com/showthread.php?t=584946)

 StheevilH Mar8-12 06:13 AM

Spontaneous drug release rate equation

Okay I found some references and the equation I am after is

Q = 2 * C * (D * t / ∏)^(1/2)

where Q is the weight of drug released per unit area (hence unit is mg/cm^2)

C is the initial drug concentration

D is the diffusion coefficient (unit of cm^2 min^-1)

and t is release time in min.

What I am not sure about is the units.

Logically the concentration of drug would be in g/L.

but when I merge all the units together, I get something else.

This is my working.

The units on the right hand side should equals to Q.

= 2 (constant) * C (g/L) * [D (cm^2 * min^-1) * t (min) / ∏ (constant)]^(1/2)

only considering units (ie discard constants)

= [g * cm^[2*(1/2)] * min^(1/2)] / [L * min^(-1 * 1/2)]

= g * cm * min^(1/2) / L * min^(-1/2)

= g * cm * min^(1/4) / L

which does not equals to unit of Q (mg/cm^2).

The units given are all correct but is there something I am missing here?

Breaking rules of powers perhaps?

Thank you!!!!

 Borek Mar8-12 08:44 AM

Re: Spontaneous drug release rate equation

You are doing strange things, difficult to follow.

What is

$$\sqrt {\frac {cm^2} {min} \times {min} }$$

equal to?

 StheevilH Mar8-12 03:34 PM

Re: Spontaneous drug release rate equation

1 Attachment(s)
Quote:
 Quote by Borek (Post 3804633) You are doing strange things, difficult to follow. What is $$\sqrt {\frac {cm^2} {min} \times {min} }$$ equal to?

I think that should equals to just "cm"

If you look at the attachment, equation 24, that is what I am after

and the units were taken from other sources.

But to me, equation makes sense but units don't

from what I did.

Is there a problem with my algebra skill?

 Borek Mar8-12 04:08 PM

Re: Spontaneous drug release rate equation

Quote:
 Quote by StheevilH (Post 3805198) I think that should equals to just "cm"
Good. Now multiply it by concentration in ## \frac {mg}{cm^3}##.

 StheevilH Mar8-12 08:20 PM

Re: Spontaneous drug release rate equation

then it would equals to mg / cm^2.... which is the unit of Q.

where did you get mg/cm^3?

oh wait... damn it.... you changed L into cm^3...

thank you so much

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