 Quote by QuantumPion
Commercial nuclear power plants are 30-40% thermodynamic efficiency in converting heat to electricity.
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Although that's only reactor heat to electricity, it doesn't include any 'efficency' of the nuclear reaction.
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No nuclear reactor or bomb of any kind can be greater than ~97.4% efficient at converting fission energy to heat because ~2.6% of the fission energy is lost to neutrinos.
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In practice of course any fission reaction only uses a very tiny proportion of the mass.
A U235 nucleus fissioning 'only' gives around 200Mev, so 235*950Mev/200Mev = 0.1% of the mass energy.