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Jan28-12, 12:06 AM
P: 1,410
Quote Quote by Curious3141 View Post
They're already doing this. Hepatitis B vaccine, for example is a recombinant subunit vaccine, where the viral surface antigen is expressed in genetically-modified yeast.

The issues with any subunit vaccine (which generally has fewer epitopes than native protein from a killed virus or bacterium) include reduced immunogenicity (which is often compensated for with adjuvants).

You might also be interested in naked DNA vaccines. Look it up.
This sounds like an incredible waste of time and effort. What do you have to do? Transfect a yeast cell with recombinant DNA and then purify the end product? You also have to deal with DNA in the first place. Why not just synthesize the protein directly? What I would like to know is, what is the current research out there on making synthetically derived short chain amino acids immunogenic? Can we improve it?

I simply don't understand why the US of freakin A doesn't treat protein synthesis like the Manhattan Project. Sure our technology these days can only synthesize peptide strands only about 100 amino acids long, but come on, people have been improving this technology since the 70s. How long until we can discover the proper organic synthesis reactions and conditions until we can create a peptide strands 1000 units long? People aren't going to give up until it happens. We need to start planning ahead of time.

What happens then when we can create peptide strands 1000 units long? 10,000 units long? All we will need is to input a computer program to synthesize our peptide strand and have it recognized by the immune system no? A protein on the surface of a bacterium can now be synthetically created and delivered with high precision, what could stop this from creating any vaccine that could treat almost any infectioous disease (as long as it isn't resistant?)?

If we could just make the antigen, no one would need "damaged" bacterial or viral cells anymore to create vaccines right?