You mean the mechanism? It would be the devices intent of treatment: MT disruption.
Or do you mean what kind of side-effects could arise from MT disruption in mature neurons?
MTs are used to traffic all kinds of vesicular traffic around the neuron, such as getting non-synaptically produced neurotransmitters in place, etc. GoogleBing "neuronal trafficking and microtubules"--Then apply imagination liberally to disruption of those processes.