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Dec5-12, 10:12 AM
PF Gold
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P: 691
I thought this was a very interesting study because it seems to question the usual relationship between insulin levels, insulin resistance and obesity:
Hyperinsulinemia is associated with obesity and pancreatic islet hyperplasia, but whether insulin causes these phenomena or is a compensatory response has remained unsettled for decades...we provide genetic evidence that pathological circulating hyperinsulinemia drives diet-induced obesity and its complications.
Hyperinsulinemia Drives Diet-Induced Obesity Independently of Brain Insulin Production

When we eat too much, obesity may develop as a result of chronically high insulin levels, not the other way around. That's according to new evidence in mice reported in the December 4th Cell Metabolism, a Cell Press publication, which challenges the widespread view that rising insulin is a secondary consequence of obesity and insulin resistance...The new study helps to solve this chicken-or-the-egg dilemma by showing that animals with persistently lower insulin stay trim even as they indulge themselves on a high-fat, all-you-can-eat buffet. The findings come as some of the first direct evidence in mammals that circulating insulin itself drives obesity, the researchers say.
Could High Insulin Make You Fat? Mouse Study Says Yes
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