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Dec7-12, 12:20 PM
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bohm2's Avatar
P: 691
I'm always very skeptical about this stuff but this was another study somewhat related to this thread (e.g. Atkins diet) that came out today arguing for a potential benefit of ketone production seen in hypocaloric and low-carb diets:
Scientists at the Gladstone Institutes have identified a novel mechanism by which a type of low-carb, low-calorie diet-called a "ketogenic diet"-could delay the effects of aging.... In the latest issue of the journal Science, available online December 6, Dr. Verdin and his team examined the role of the compound β-hydroxybutyrate (βOHB), a so-called "ketone body" that is produced during a prolonged low-calorie or ketogenic diet. While ketone bodies such as βOHB can be toxic when present at very high concentrations in people with diseases such as Type I diabetes, Dr. Verdin and colleagues found that at lower concentrations, βOHB helps protect cells from "oxidative stress" -- which occurs as certain molecules build to toxic levels in the body and contributes to the aging process.
How Calorie Restriction Influences Longevity: Protecting Cells from Damage Caused by Chronic Disease

The original paper:

Suppression of Oxidative Stress by β-Hydroxybutyrate, an Endogenous Histone Deacetylase Inhibitor