DNA Replication


by elemis
Tags: replication
elemis
elemis is offline
#1
Apr24-12, 12:16 PM
P: 157
Before I ask my question, I would like to state that I am not a Biology student. I am actually a Chemistry student who has a small section on Biochemistry in his syllabus.

Now, my problem lies with part (ii).

Mechloroethamine obviously hold the DNA strands together and prevents the DNA helix from uncurling/unzipping. Hence, the very first stage in replication is impeded.

How cis-platin affects DNA replication is eluding me. I know that Guanine normally forms 3 hydrogen bonds with Cytosine. However, it seems to be forming only one hydrogen bond in this case.

Could someone prod me in the correct direction ?
Attached Thumbnails
cis.png  
Phys.Org News Partner Chemistry news on Phys.org
First view of nature-inspired catalyst after ripping hydrogen apart provides insights for better, cheaper fuel cells
Following a protein's travel inside cells is key to improving patient monitoring, drug development
Team helps cancer treatment drugs get past their sticking point
Abod
Abod is offline
#2
Apr24-12, 12:52 PM
P: 6
Read this, it might be helpful.
aroc91
aroc91 is offline
#3
Apr24-12, 01:04 PM
P: 160
This should help as well-

http://pharmacologycorner.com/cispla...deo-animation/


Register to reply

Related Discussions
can matter and anti matter manipulation be used for replication of Special & General Relativity 1
Regarding DNA/RNA replication Biology 3
Operons and DNA replication Biology 3
DNA Replication Biology 5
DNA Replication Correction Biology 5