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Names of these two compounds?

by hivesaeed4
Tags: compounds, names
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hivesaeed4
#1
Dec20-12, 12:21 AM
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Could someone give the proper chemical names of the attached two compounds.
Lots of thanks in advance.
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Lead molecule X.jpg   Lead molecule from HTS.png  
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Borek
#2
Dec20-12, 03:09 AM
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Have you tried ChemSketch? Or chemspider.com?
chemisttree
#3
Dec20-12, 11:33 PM
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The second structure looks like the hydrazone of 2-hydroxy-1-napthalenecarboxaldehyde or 2-hydroxy-1-napthalenecarboxaldehyde hydrazone

Mandelbroth
#4
Dec21-12, 03:35 PM
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Names of these two compounds?

Quote Quote by chemisttree View Post
The second structure looks like the hydrazone of 2-hydroxy-1-napthalenecarboxaldehyde or 2-hydroxy-1-napthalenecarboxaldehyde hydrazone
Maybe a little...? I don't see very much similarity...

Quote Quote by hivesaeed4 View Post
Could someone give the proper chemical names of the attached two compounds.
Lots of thanks in advance.
Based on the picture, I'm thinking that these are part of a biomolecular pathway involving gamma secretase, right? On a quick inspection (it's been a while since I did any biochem), it looks like your second compound might be the result of hydrolysis occurring in the first compound between the right-most nitrogen in the picture and the carbon to the right of it.

You may want to look at various products, substrates, etc. of gamma secretase reactions; it is likely that your answer lies there.
chemisttree
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Dec21-12, 11:46 PM
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For the second structure, chemspider.com loads the correct structure with the input name of 2-hydroxy-1-napthalenecarboxaldehyde hydrazone but it is also known as 1-hydrazonomethyl-2-naphthol. Your picture doesn't indicate which isomer, E or Z, it should be but if you were to include that, the name would also be 1-[(EorZ)-hydrazonomethyl]-2-naphthol.
hivesaeed4
#6
Dec22-12, 03:07 AM
P: 217
Lots of thanks.


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