Here is a geometric interpretation.
Consider a system of particles. Add up their 4-momenta [using either the parallelogram rule or the tail-to-tip method] and obtain the resultant 4-momentum vector. The center of momentum is the reference frame with unit vector tangent to that resultant 4-vector.
In the current frame, this vector has components of the form

,
where

is the velocity of that center-of-momentum-frame.
Writing
we can express that velocity as the ratio of relativistic-spatial-momentum to relativistic-energy:

.
In that center of momentum frame, the relativistic-spatial-momentum

in that frame is zero.
In short, the center-of-momentum-frame is along the resultant,
and the velocity of that frame [with respect to our frame] is "the slope of the resultant" in our coordinates.