Topological charge in Quantum Chromodynamics (QCD) refers to an integer value that characterizes the topological properties of a manifold, often exemplified by the number of holes in a surface like a sphere or torus. In QCD, multiple equivalent vacua exist, linked by global transformations, with instantons representing the tunneling between these vacua. The discussion illustrates this concept using an analogy of masses on a rope, where fixing two masses while allowing oscillations creates a "knot" that reflects a non-zero topological charge, or winding number. This relationship highlights the connection between instantons and solitons in the context of QCD. Understanding topological charge is crucial for grasping the vacuum structure and dynamics in QCD.