Can anybody tell me what are Phosphopepitdes?

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Discussion Overview

The discussion centers around the definition and understanding of phosphopeptides, exploring their composition and the biochemical processes involved in their formation. The scope includes conceptual clarification and technical explanation related to biochemistry and protein modification.

Discussion Character

  • Conceptual clarification, Technical explanation

Main Points Raised

  • One participant seeks clarification on the term "phosphopeptides."
  • Another participant explains that "peptide" refers to amino acids and "phospho" indicates the presence of a phosphate group, suggesting that a phosphopeptide is an amino acid bonded with a phosphate group.
  • A further elaboration indicates that specific amino acids such as serine, threonine, and tyrosine can have phosphate groups added by protein kinases, leading to the formation of phosphoproteins, and that a phosphopeptide can be derived from a phosphorylated section of a protein.

Areas of Agreement / Disagreement

Participants generally agree on the basic definition of phosphopeptides and the biochemical context, but there is no explicit consensus on the term's usage or implications beyond the initial definitions provided.

Contextual Notes

The discussion does not address potential variations in the definition of phosphopeptides or the specific conditions under which phosphorylation occurs, leaving some assumptions and details unresolved.

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Can anybody tell me what are Phosphopepitdes ??
 
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I've not come across the term before, but peptide denotes amino acids (polypeptides= proteins, peptide bonds join amino acids, etc...) and phospho means with a phosphate group attached (as in phospholipid, phosphorylisation). From this I'd assume an amino acid bonded with a phosphate group.
 
mattyaouw's got it right, but to elaborate a little more...specific amino acids namely serine, threonine and thyrosine contain -OH side chains which can be acted on by any number of protein kinases (enzymes) which can then add a phosphate group. Typically this happens in whole proteins as part of the modification of enzyme activity via phosphorylation, in this case it can be called a phosphoprotein. If you were to cut out the section of the protein containing the phosporylated amino acid(s) you would then have a phosphopeptide.
 
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