Red blood cell general concepts.

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Discussion Overview

The discussion revolves around general concepts related to red blood cells, specifically focusing on tonicity, osmolarity, and the transport of polar molecules across the cell membrane. Participants are exploring foundational biological principles and seeking clarification on their understanding.

Discussion Character

  • Conceptual clarification
  • Debate/contested
  • Technical explanation

Main Points Raised

  • One participant describes how red blood cells behave in hypotonic, isotonic, and hypertonic solutions, noting that hypotonic solutions can cause cell lysis, isotonic solutions have no effect, and hypertonic solutions lead to cell shrinkage.
  • Another participant questions the use of terms hypo- and hypertonic, suggesting that the definitions should clarify whether they refer to the cell or the surrounding solution.
  • There is a discussion about osmolarity and concentration, with one participant expressing confusion about how different solutes at the same concentration can have different osmolarities.
  • Concerns are raised about the transport of polar molecules across the red blood cell membrane, with a focus on how size and polarity affect diffusion rates.

Areas of Agreement / Disagreement

Participants generally agree that there are errors in the initial understanding of tonicity and osmolarity, but they do not reach a consensus on the definitions or implications of these concepts. The discussion remains unresolved regarding the clarity of these terms and their applications.

Contextual Notes

Participants express uncertainty about the definitions of osmolarity and concentration, and how different solutes can affect osmolarity despite having the same concentration. There is also ambiguity regarding the transport mechanisms for polar molecules.

nemzy
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Can anyone correct me if I am wrong? This is basic basic basic basic basic basic biology, and i am just trying to refresh my memory and make sure that i am stating the correct facts

1) General concepts about tonicity
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Lets say for example, we have a red blood cell exposed to solutions of different tonicity (hypo, iso, hyper)

If the red blood cell was hypotonic to the solution, then the red's blood cell volume will increase, and ultimatey lysing the cell.

If the red blood cell was iso to the solution, it will make no differenfce

If the red blood cell was hyper to the solution, the cell would shrivel as water will leave the cell and thus losing volume in the red blood cell.

2) Let's say for example, the isotonic concentrations for the red blood cell's was exposed to different solution of increasing osmlarity but equal concnetration. If this was to happen, osmosis would be in equilibrium, since osmosis is only determnined only by a difference in total solute concentration, nut just spefically different solutions.

3) If polar molecules of increasing molecular weight was introduced to the red blood cell plasma membrane, then how would the rate of transport across the red blood cell membrane change? Well, first of all , it is very hard for a polar molecule to pass thru the membrane, let alone the size. So, the rate of transport across the red blood cell membrane would greatly be reduced.


So am i stating the correct facts. Or are they any more stuff that can be added to my concepts? If I am wrong anywhere, can you show me where and why?

thanks
 
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There are some errors, so I'll try to offer some hints for you to find them yourself (you'll remember it better if you find your own mistakes).
1) You're saying the (contents of the) red cell are hypo- or hypertonic relative to the solution it is in. What does that mean in terms of ion concentration inside the cell, and outside the cell (outside=solution)? Be careful whether you are referring to the contents of the cell as hypo/hypertonic, or the solution as hypo/hypertonic relative to the other.

2) What is the definition of osmolarity? What is the definition of concentration?
 
i see...

for 1) i should have said the solution "..." to the cell instead of the other way around.

for 2) osmorality is defined as solute concentration defined as molarity (moles of solute/liters). What exactly is concentration?? Ahh sorry for asking such a stupid question...

and i am totally clueless on how different solutes at the same concentration cuold hvae different osmolarities

also for 3)..is my conceptual thinking right on this part?

thanks
 
nemzy said:
for 2) osmorality is defined as solute concentration defined as molarity (moles of solute/liters). What exactly is concentration?? Ahh sorry for asking such a stupid question...

and i am totally clueless on how different solutes at the same concentration cuold hvae different osmolarities

That's why I asked you to define both osmolarity and concentration. Osmolarity (molarity) is a measure of concentration. That part of the question made no sense to me, unless you're attempting to use two different measures of concentration. For example, if you are talking about two different solutes, then the solutions made from them could have the same osmolarity, but concentration as measure in g/mL would be different because that would depend on the molecular weight. But, in terms of diffusion, weight/volume measures of concentration aren't relevant, it's molarity that matters.

also for 3)..is my conceptual thinking right on this part?

thanks

As long as you're talking about the ability of molecules of different sizes to diffuse into a cell (it wasn't completely clear from the wording of the question). From the general trend of the questions, I assume they are all referring to simple diffusion.
 

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