What’s something that turned out to be much harder to do?

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In 1900, people predicted we would not fly for another 1000 years. Yet in 1903 we had the first manned flight and 66 years later-we went to the moon. These things were much more doable than we thought but it is 2026 and we still do not have a cure for baldness or a reliable male birth control pill.


What are some other examples? Stuff like FTL and anti-gravity don’t count as they might be inherently impossible
 
on Phys.org
Commercial utility-scale fusion power generation.
 
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- Cloning mammals. Dolly the sheep was a bit of a surprise.
- Gene editing (CRISPR etc.). Still early days, but I doubt Watson, Crick, or Pauling ever thought it would happen so soon.
- Rapid, low cost DNA sequencing. Francis Collins didn't expect Craig Venter to do it that way.
- Photograph of a black hole.
- The www. It all started as a DoD and University thing, then it went commercial and changed the world.