As a reminder of ideas that came up in the thread so far---for revitalizing the String program. What I'm hoping for are suggestions from other people along these and different lines. Those offered so far might not necessarily be viable or appropriate to the problem.
1.
incorporate measurement process in the model
represent experiment/observation mathematically in the picture---so it is less about what nature is supposed to be made of and more about how it responds to measurement.
2.
get a quantum cosmology we can test
mathematical representation of the geometry of the universe. Science has always been driven by this quest, from its beginnings in the 6th century BC.
3.
resolve the singularity
IMHO probably this is the main job of quantum cosmo in our time
4.
clearer focus and direction
the risk of having too much recital about how this and that is "string-inspired" and "string-related"---the String program does not own SUGRA and supersymmetry. they are shared resources that exist independently without string. Likewise dualities (other theories have them as well). To have a clear direction it is not enough to pursue Sugra and AdS-stuff and invoke some remote connection
5.
geometry fully interactive with matter.
the need to break free from prior geometry. Einstein's reciprocity principle of no one-way influences in nature. No degrees of freedom which act on others but are not themselves acted upon.
6.
avoid getting too elaborate and Baroque
two people in the thread mentioned Ptolemaic epicycles and Aristotelian physics. I don't know if that is a fair analogy. There was a clever exchange about it. Hermann Nicolai used the word Baroque in his 2009 talk at the Max Born symposium. So it is a concern of insiders. "becoming increasingly Baroque, if you follow the literature." Of course he is still writing string papers, as he should be! But he frankly and honorably avows his misgivings.
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EDIT: Hi Fzero, nice to see a post from you here! I will reply briefly simply by editing this. Indeed it is nice that string math is serviceable and versatile. It is useful in several contexts (as you mentioned) and can provide the most economical way to derive something---at least that we know of as yet.
You need not imagine that I find this upsetting! I welcome it
Speaking of dualities (as you were) you might be interested in this:
http://arxiv.org/pdf/1010.2481
Einstein gravity as a 3D conformally invariant theory
Henrique Gomes, Sean Gryb, Tim Koslowski
27 pages. Published in Class.Quant.Grav.28:045005,2011
Each of the three authors is giving a talk at Loops 2011 this month in Madrid.
EDIT: brief reply to Fzero and Haelfix. Thanks to both for these thoughtful responses! (#239 and 240) Food for thought.