Isotope Exchange Deuterium: Mechanism & Labeling

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SUMMARY

The discussion centers on the mechanism of isotope exchange involving deuterium and its application in labeling compounds. Participants highlight the use of deuterated solvents, such as heavy water and deuterated chloroform (CDCl3), for replacing hydrogen with deuterium. The distinction between isotope exchange and isotope labeling is also clarified, emphasizing that simple M-H bonds can be effectively treated by dissolving in deuterated solvents. Infrared spectroscopy and mass spectrometry are identified as key analytical techniques for detecting isotopic changes.

PREREQUISITES
  • Understanding of isotopic chemistry and deuterium
  • Familiarity with deuterated solvents, specifically heavy water and CDCl3
  • Knowledge of infrared spectroscopy and mass spectrometry techniques
  • Basic concepts of chemical bonding, particularly M-H bonds
NEXT STEPS
  • Research the mechanism of deuterium incorporation in organic compounds
  • Explore the differences between isotope exchange and isotope labeling
  • Learn about the applications of infrared spectroscopy in isotopic analysis
  • Investigate mass spectrometry techniques for detecting isotopic variations
USEFUL FOR

Chemists, researchers in organic synthesis, and students studying isotopic labeling techniques will benefit from this discussion.

baqi
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Deuterium is heavier then Hydrogen so a metal bonded to H vs. C can be determined by isotopic exchange and then using Infrared Spectroscopy/mass spec. But how do you replace hydrogen with deuterium?

a.Dehydrogenation and then add deuterated solvents (heavy water or CDCl3 ..deuterated chloroform)?
b.Just dissolve cpd in deuterated solvent?

I have doubts about the above mentioned applications…so how what is the meachanism?

Thanks for your help

Wait …what is the difference between isotope exchange vs. isotope labeling?

Thanks
 
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opos I think this should have been under the homework "other sciences" section...So sorry!

back to the question I think if you have some thing as simple as a M-H bond you can just dissolve it is deuterated solvents! ~ right?