Skewness affects the reliability of the mean as a measure of central tendency, indicating that a non-zero skew suggests the average may not accurately represent the data. In skewed distributions, the median is often a better measure, as it balances observations on both sides. The average, or mean, is defined as the sum of sample values divided by the number of samples, while the median and mode serve different purposes. The discussion also touches on the discrepancies between theoretical predictions and experimental results in quantum theory, raising questions about when a theory should be revised based on experimental data. Ultimately, the choice of measure of central tendency should align with the specific analytical needs.