Solve Stats Problem: High School Aspirin & Myocardial Infarction

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SUMMARY

This discussion focuses on a high school statistics problem involving a study by the Physician’s Research Group at Harvard, which investigated the impact of aspirin on myocardial infarction rates. The study was a 5-year randomized, blind trial comparing aspirin users to a placebo group. Key tasks include producing a 95% confidence interval for the difference in proportions of heart attacks between the two groups and calculating the odds ratio for the same. The early publication of results is justified by the significant findings that emerged during the study.

PREREQUISITES
  • Understanding of confidence intervals in statistics
  • Knowledge of odds ratios and their calculation
  • Familiarity with hypothesis testing and statistical significance
  • Basic concepts of randomized controlled trials
NEXT STEPS
  • Learn how to calculate a 95% confidence interval for proportions
  • Study the methodology for calculating odds ratios in clinical trials
  • Research the implications of early publication of study results in medical research
  • Explore the use of F-tests in comparing variances between groups
USEFUL FOR

High school students studying statistics, educators teaching statistical methods, and anyone interested in understanding the relationship between medication use and health outcomes.

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I have to do this problem for my high school stats class. I have no idea where to start. Can someone please show me how to do this and help me find out the answers? Thanks.

The following table was taken from a report on the relationship between aspirin use and myocardial infarction by the Physician’s Research Group at Havard. The physician’s study was a 5-year randomized study testing whether regular intake of aspirin reduces mortality from cardiovascular disease. Every day, physicians participating in the study either took one aspirin or a placebo. The study was blind. The results of the study were actually published well before the study ended. Based on the data, explain why the doctor’s running the study published their results early. Justify your position.

Myocardial Infarction
Aspirin- Yes(104) No(10933)
Placebo- Yes(189) No(10845)

1. Produce a 95% confidence interval for the difference of proportions between the Aspirin group that had heart attacks and the Placebo group that had heart attacks (Myocardio Infarction=yes)

2. Produce a 95% confidence interval for odds ratio of Aspirin group that had heart attacks to the Placebo group that had heard attacks (Myocardio Infarction).

3. Does the interpretation of these two confidence intervals agree with each other? Justify why or why not?
 
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Ynot use F-Test ??
 

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