MHC peptides

[karthik3k]

What are the Diseases involving MHC peptides ???



Where can i find about peptide vaccines ???

[iansmith]

MHC are Major Histocompatibility Complex. This peptides are used to differentiated between self and non-self. Because MHC are part of the immune system, the disease associate with it are usualy auto-immune disease. The Sanger institute has a nice list of MHC-linked diseases (http://www.sanger.ac.uk/HGP/Chr6/MHC/diseases.shtml). More info on MHC and Diseases (http://immune.ucalgary.ca/IRG.nsf/bae0cdabe27c995d87256d5900628b5c/$FILE/ATT0FSSQ/639.02%20mhc%20lect%201a.pdf)

For peptide vaccine there some review if you can get access to papers
Lipopeptide vaccines--yesterday, today, and tomorrow (http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6W8X-469GF8Y-R&_coverDate=07%2F01%2F2002&_alid=166811089&_rdoc=1&_fmt=&_orig=search&_qd=1&_cdi=6666&_sort=d&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=66e1f5a9b7b8562433f9474e968b60ed)
Antigenicity and immunogenicity of synthetic peptides. (http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WBS-457VDY3-9&_coverDate=09%2F30%2F2001&_alid=166811176&_rdoc=1&_fmt=&_orig=search&_qd=1&_cdi=6718&_sort=d&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=04551ade86da55ccb4c5172365e90aaf)

[karthik3k]

I want specifically for Class 1(confirmed) and it should involve antigen presentation.

[iansmith]

MHC class I antigen processing pathway defects, ras mutations and disease stage in colorectal carcinoma. (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=14750179&dopt=Abstract)

[karthik3k]

Hey thanks.
I have decided to work on Melanoma.
Tell me how can i design a peptide vaccine "insilico" for this ???

[iansmith]

First you would have to identify surface protein(s) or component that is/are unique to Melanoma and present on many different individuals. After you just test the "antigenicity" of each component.

You should check to following paper
From genome to vaccine: in silico predictions, ex vivo verification. (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&dopt=Citation&list_uids=11483263)

[aychamo]

How do you always find all these papers??

[iansmith]

I use PubMed (http://www.ncbi.nlm.nih.gov/PubMed/) or Google (http://www.google.ca) with the right combination of words. For example I use these terms "In silico" vaccine design in pubmed for the last paper. Finding the right paper is always a matter of choosing the proper term with the search engine.

[Monique]

the use of quotation marks can be very usefull, google also supports the search of certain filetypes, for instance.. filetype:pdf, or site:.edu, or site:physicsforums.com