A vaccine targeting mutant IDH1 in newly diagnosed glioma

  • Thread starter Greg Bernhardt
  • Start date
  • Tags
    Vaccine
In summary: There are also ongoing trials using vaccines as part of cancer immunotherapy.This particular study is aimed at testing the effectiveness of an IDH1-specific peptide vaccine (IDH1-vac) in patients with newly diagnosed IDH1+ astrocytomas. The study is a multicentre, single-arm, open-label, first-in-human trial, and so far 33 patients have been enrolled. The patients have been given either IDH1-vac or a placebo, and the study is currently ongoing.So far, the results of the study look promising. Specifically, the study has found that IDH1-vac is effective in treating IDH1+
  • #1
Greg Bernhardt
Admin
Insights Author
19,443
10,021
Mutated isocitrate dehydrogenase 1 (IDH1) defines a molecularly distinct subtype of diffuse glioma1,2,3. The most common IDH1 mutation in gliomas affects codon 132 and encodes IDH1(R132H), which harbours a shared clonal neoepitope that is presented on major histocompatibility complex (MHC) class II4,5. An IDH1(R132H)-specific peptide vaccine (IDH1-vac) induces specific therapeutic T helper cell responses that are effective against IDH1(R132H)+ tumours in syngeneic MHC-humanized mice4,6,7,8. Here we describe a multicentre, single-arm, open-label, first-in-humans phase I trial that we carried out in 33 patients with newly diagnosed World Health Organization grade 3 and 4 IDH1(R132H)+ astrocytomas (Neurooncology Working Group of the German Cancer Society trial 16 (NOA16), ClinicalTrials.gov identifier NCT02454634).

Are cancer vaccines a super new thing? I have not heard of a vaccine for cancer before.
https://www.nature.com/articles/s41586-021-03363-z
 
  • Like
Likes Astronuc
Biology news on Phys.org
  • #3
Greg Bernhardt said:
Are cancer vaccines a super new thing? I have not heard of a vaccine for cancer before.
https://www.nature.com/articles/s41586-021-03363-z

The idea of creating a vaccine to prime the immune system to attack cancer is fairly new, though many groups are working on this idea. For example, here's a PF thread from 3 years ago discussing research related to anti-cancer vaccines: https://www.physicsforums.com/threads/new-cancer-research-at-stanford.938605/

Here's a more general article on the topic: https://www.cancerresearch.org/immunotherapy/treatment-types/cancer-vaccines

The idea of anti-cancer vaccines is related to the broader idea of cancer immunotherapy, which is one of the big new ideas in cancer research. Basically, the goal of cancer immunotherapy is to use the body's own immune system to fight cancer. Current cancer immunotherapy drugs being used in the clinic include checkpoint inhibitor therapy (which helps get around defenses that cancer cells use to hide from the immune system; this idea was awarded the Nobel Prize in Medicine in 2018) and CAR-T therapy (which involves engineering immune cells to better be able to fight cancer cells).
 
  • Like
  • Informative
Likes Astronuc, Greg Bernhardt, BillTre and 1 other person

What is a vaccine targeting mutant IDH1 in newly diagnosed glioma?

A vaccine targeting mutant IDH1 in newly diagnosed glioma is a type of treatment that aims to stimulate the immune system to recognize and attack cells with a specific mutation (IDH1) found in glioma, a type of brain cancer.

How does this vaccine work?

This vaccine works by introducing a small piece of the mutated IDH1 protein to the immune system, which then triggers an immune response to target and destroy cells with this mutation.

Who can benefit from this vaccine?

This vaccine is specifically designed for individuals who have been newly diagnosed with glioma and have the IDH1 mutation. It is not currently recommended for those with recurrent or advanced glioma.

What are the potential side effects of this vaccine?

As with any medical treatment, there are potential side effects associated with this vaccine. These may include mild flu-like symptoms, such as fever, chills, and fatigue. More serious side effects are rare but may include allergic reactions or neurological symptoms.

Is this vaccine a cure for glioma?

While this vaccine shows promising results in early studies, it is not yet considered a cure for glioma. It is still being researched and evaluated in clinical trials, and its effectiveness may vary from person to person. It is important to consult with a healthcare professional for personalized treatment options.

Hot Threads

Recent Insights

Back
Top