Is a Triple Helix DNA Structure Possible and What Are Its Implications?

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Discussion Overview

The discussion centers around the possibility of a triple helix DNA structure, exploring theoretical implications, advantages, and disadvantages. It also touches on the creation of hypothetical base pairs that do not currently exist, considering both theoretical and practical aspects.

Discussion Character

  • Exploratory
  • Debate/contested
  • Conceptual clarification
  • Technical explanation

Main Points Raised

  • Some participants question whether a triple helix DNA structure could exist and what potential advantages or disadvantages it might have.
  • One participant suggests that it is theoretically possible to create additional nucleic acids for a middle strand in a triple helix, but notes that practical implementation may be hindered by hydration issues.
  • Another participant mentions that triple helices are known to occur in transient situations during DNA recombination, such as during gamete fertilization.
  • There is a discussion about the feasibility of creating artificial base pairs that could function similarly to existing ones, though one participant expresses skepticism about the likelihood of this due to the precise positioning of DNA molecules.
  • A participant shares an anecdote about a biology teacher's response to the existence of a natural triple helix, indicating a lack of awareness of the transient situations mentioned earlier.

Areas of Agreement / Disagreement

Participants express varying views on the existence and implications of a triple helix DNA structure. While some acknowledge the possibility of transient triple helices, others remain uncertain about the practicality of creating new base pairs or the advantages of a stable triple helix.

Contextual Notes

The discussion includes assumptions about the structural dynamics of DNA and the conditions under which a triple helix might form, which are not fully resolved. The feasibility of artificial base pairs is also contingent on various biochemical interactions that are not definitively established.

Who May Find This Useful

This discussion may be of interest to those studying molecular biology, genetics, or biochemistry, particularly in the context of DNA structure and function.

Zelos
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the dna is made up be a double helix, but would it be possible to have a tripple helix? if so what would the advantage be and what disadvantages does exist? I've been thinking on this and have come nowhere exept it would be fun to see it cause we don't have it.

and is it possible to create (theoretical on paper) base pairs we don't have that could acctualy work(theoretical)?
 
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Zelos said:
and is it possible to create (theoretical on paper) base pairs we don't have that could acctualy work(theoretical)?

yes. put an additional nucleic acid on the 1 carbon of the ribose for the middle strand. whether this would work in reality is another matter, since your inner core of the cylinder would most likely be hydrated.

linus pauling originally (and mistakenly) thought that DNA was a triple helix.
 
oh hey zelos, I didn't know you joined.
 
The triple helix has been known to exist in transient situations. Whenever DNA recombination occurs such as in crossing over during gamete fertilization, aided by enzymes such as recombinases and invertases, and possibly during replication and transcription occurs.

As for the artificial base pairs... if you can make basepairs that can interact in the same manner with the various enzymes and biomolecules that chemically "touch" the DNA for information, then you can replace the base pairs we have now with no consequences. This, however, is not very likely because I suspect that every fraction of an angstrom of the DNA molecule is dynamically positioned in such a precise way.
 
Zelos, I asked my biology teacher if there was such a helix that existed naturally. He told me if I could find one then I'd be looking at a Nobel Prize in Biology. I guess he didn't know about the transient situations Quasi just mentioned.

Quasi, what would an example of one of those situations be?

What would the advantages of such a helix be? Wouldn't that be fun to decode! :bugeye:

~Kitty
 

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