Originally Posted by mathman
There is no closed form expression for Prob. (other than the exact formula). However for large n, the binomial can be approximated by the normal distribution when p is fixed. In the case you are describing (np fixed), the Poisson distribution is a good approximation.
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Unfortunately using the normal distribution yields 50%, which is not true when the discrete character isn't lost. For Poisson I'm not sure where to put in my 2 variables n and p :(
Btw, this problem I thought of when trying to think of how likely a "statistical statement" would be. With the odds 1:N for example you can be 63% (

) sure that at least 1 of a N people is "positive".