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Amide coupling reagents

by gravenewworld
Tags: amide, coupling, reagents
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Aug4-04, 07:04 AM
P: 1,408
I'm trying to find a coupling reagent for reacting an amine with a carboxylic acid. Currently I am using TBTU with fenchyl amine hydrochloride, but the amine seems not to want to react witht the carboxylic acid. Are there some better coupling reagents than TBTU out there that anyone knows of?
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Aug4-04, 10:51 AM
Sci Advisor
P: 284
Here's a whole list of them:

They've got the CAS numbers listed there so you can cross-reference them to a chemical catalog.

I would say the ones I have seen the most often are CDI, HOBT, DCC, and EDCI.
Aug4-04, 11:18 AM
P: 1,408
awesome thanks!

Aug5-04, 12:07 AM
P: 210
Amide coupling reagents

I don't have anything to contribute to this thread, however you two dudes seem into this whole chemistry game.

Perhaps you'd be interested in the following forum:

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