|Jul13-10, 09:36 PM||#1|
Are cofactors consumed in the reaction?
I have a quick clarification. Enzymes are not consumed in the reaction but cofactor like NAD+ is consumed in reaction right. So does NAD+ first bind to the enzyme and then get reduced in certain reactions? Thanks
|Jul13-10, 11:27 PM||#2|
"Cofactor" really means anything that's not an amino acid which is bound to the enzyme and required for it to function. A cofactor like NAD+/NADH usually participates as an electron acceptor/donor in the reaction, so it's part of the reaction.
On the other hand a metal ion might just sit in the protein and coordinate to a couple of negatively charged ligands and have a purely structural role, with no participation at all. And the cytochrome cofactors in Cytochrome C Oxidase participate in the reaction, but act as catalysts and aren't consumed.
So 'cofactor' doesn't imply anything about whether or not it plays a role in the reactivity.
|Jul14-10, 06:38 PM||#3|
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