Human Genome Project: Results & Interactions

[drdolittle]

Can somebody help me in giving information about the results of Human Genome Project.i hope there ultimate aim is to find out all the possible combinations of available 30000-400000 chromoomes in human body.Were they able to draw the expected results? My second question is whether any possible sources available dealing with the INTERACTION OF GENES.If so,please do let me know.

regards
drdolittle

"i think that he thinks that i think that he thinks"

 

[Monique]

hi drdolittle, there were two independent research groups (one private, one public) that analyzed the sequence of the 3 billion base that make up the human genome; they also analyzed many other genomes. You can find information on the publicly funded project at this website http://www.ncbi.nlm.nih.gov/Genomes/

By knowing the exact sequence of bases, it's like they were able to write down sentences of a book. Right now they are in the process of analyzing those sentences to see which genes are in them and how those genes work. A major advantage of knowing multiple genomes is that you can compare them with each other and thus gather information about conserved regions.

There are also resources on the interaction of genes, I guess you'd be interested in protein interaction maps. Recently the protein interaction map of the fruitfly was published in Science.. I'm not sure whether there's a database available yet.

 

[Sho'Nuff]

Perhaps you've seen the elegant universe on relativity, there's a similar program on the race for finishing the human genome project between Craig Venter and Eric Lander.
You'll get an explanation by the guys that did the job, great fun...
http://www.pbs.org/wgbh/nova/genome/program.html

 

[Sho'Nuff]

I believe Mark Vidal pioneered protein interaction maps in yeast and follow up work has been done to reate interaction maps of the Drosophila proteome meaning massive yeast-2-hybrid assays. Heres a free database were you can find what your protein of interest interacts with http://biodata.mshri.on.ca/fly_grid/servlet/SearchPage you need to find the drosophila ortholog of your protein though...if its conserved at all.