Why are there no adenosine agonists available?

by CrimpJiggler
Tags: adenosine, agonists
CrimpJiggler is offline
Oct9-12, 06:17 AM
P: 149
Various xanthine alkaloids such as caffeine, theophylline and theobromine produce stimulant effects because they are adenosine receptor antagonists. Would adenosine agonists not make good sedatives/tranquilisers?
Phys.Org News Partner Medical research news on Phys.org
Pregnancy complications may be more common in immigrants from certain regions
Use of frozen material for fecal transplant successfully treats C. difficile infection
Death rates from pancreatic cancer predicted to rise in Europe in 2014
Carvacrol is offline
Oct9-12, 05:10 PM
P: 1
Because adenosine doesn't works like histamine?

Edit: Caffeine withdrawal syndrome is unpleasant, and it is caused by an excess of adenosine receptors. Adenosine causes vasodilatation, and too much causes headaches and nausea.
Painful headaches don't help sedation and tranquilisation. Therefore I think an adenosine agonist wouldn't be a good sedative/tranquiliser.
Pythagorean is offline
Oct10-12, 04:49 AM
PF Gold
Pythagorean's Avatar
P: 4,212
Hospitals keep adenosine itself around as an agonist for treating tachychardia, to slow down the heart.

Adenosine acts as a break in biological systems, having inhibiting effects, but caffeine doesn't just stop this break, it also makes other neurotransmitters more active. For instance, it prevents breakdown of acetylcholine (ACh), so ACh sticks around longer, increasing its effect.

Register to reply

Related Discussions
Benzodiazepine withdrawal syndrome and inverse BZ agonists Medical Sciences 0
Are all benzodiazepines GABA agonists? Medical Sciences 3
dopamine agonists and dopamine antagonists Medical Sciences 14
Will too much adenosine triphosphate kill you? Biology 12