Recent content by JonMoulton

From the Oligonucleotide Therapeutics Society: "Can Oligonucleotides Target RNA Splicing to Treat Disease?" https://www.oligotherapeutics.org/can-oligonucleotides-target-rna-splicing-to-treat-disease/

Giuseppe Ronzitti. Let’s switch on AAV! Sci Transl Med. 2020;12(579) doi:10.1126/scitranslmed.aba9016 (editorial) https://stm.sciencemag.org/content/12/529/eaba9016 This describes a virally delivered ribozyme modulated by a Morpholino oligo. Press release...

The search keywords "wobble base" might help.

If you can fund it, the double major would be great background. I doubled majored in Chemistry and Biology; it was very useful in grad school and has been very useful in industry.

Watching dynamics of RNA expression - paper describing a visualization technique. Movie 1 from supplemental information: in a zebrafish embryo, DNA is stained with red fluorescence and carboxyfluoresceinaed Morpholino oligos targeting dre-miR-430 emit visible green fluorescence when they reach...

mod: approved HexSim Life History Simulation Modeling Platform - free to download. Landscape ecology, anyone? After >10 years of development, the HexSim life history simulator is ready for use by students and researchers.HexSim is a free, versatile, multi-species, life history simulator ideal...

And, as there is some controversy about the clinical benefit, this is just the sort scenario for which accelerated approval was legislated. Congress set up accelerated approval to get potentially useful medications to those in dire need prior to proof of clinical efficacy. DMD is a serious...

A Morpholino antisense drug has been approved by the US FDA. http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm521263.htm This drug binds to complementary RNA to change biology, in this case altering the splicing of the protein that, when mutated, can cause Duchenne muscular...

No fair using the "Beatle" spelling as clickbait. Your beetle doesn't care too much for sugar, veggies can't buy you love.

I'll give a shot at considering the problem in a research-free fashion. Need: # of bases in the human genome average % difference in base sequence between siblings Calculate the average number of bases different. Consider that the odds of randomly matching bases is 1/(4^n) where n is the...

Here's a new paper on the topic, discussing gene flow between kingdoms. http://www.plosgenetics.org/article/info%3Adoi%2F10.1371%2Fjournal.pgen.1003877 "A Review of Bacteria-Animal Lateral Gene Transfer May Inform Our Understanding of Diseases like Cancer "

PubMed will give citations and abstracts for both open-access and pay-walled papers. You can visit http://www.plos.org/ to see some open-access journals only. Try PLoS Biology and PLoS one.

Dunno about you, Dremmer, but I sure am. And a mammal, and even a primate at that. Woop woop!

This is out of my current field, but I read some papers on entropy in complex systems back in grad school. I recall that Stewart Kauffman was a key researcher in that field. I see in PubMed that he's still working in complex system thermodynamics -- you might look at his stuff. PubMed search...

Here's another vote for Scientific American. Another good source is American Scientist, which might contain a bit more mathematics (usually not too difficult for a freshman/sophomore bio major). You'll find one or two bio articles in each issue of either of these magazines. Try the Annual...