Switching a transgene with a Morpholino oligo

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TL;DR
New approach for controlling expression from a transgene
Giuseppe Ronzitti. Let’s switch on AAV! Sci Transl Med. 2020;12(579) doi:10.1126/scitranslmed.aba9016 (editorial)
https://stm.sciencemag.org/content/12/529/eaba9016

This describes a virally delivered ribozyme modulated by a Morpholino oligo.

Press release
https://www.eurekalert.org/pub_releases/2019-12/sri-nta122419.php

Primary paper
Zhong G, Wang H, He W, Li Y, Mou H, Tickner ZJ, Tran MH, Ou T, Yin Y, Diao H, Farzan M. A reversible RNA on-switch that controls gene expression of AAV-delivered therapeutics in vivo. Nat Biotechnol. 2019;[Epub ahead print] doi:10.1038/s41587-019-0357-y.
https://www.nature.com/articles/s41587-019-0357-y
 
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This is an interesting study! It looks like the authors have developed a novel ribozyme on-switch to modulate gene expression of AAV-delivered therapies in vivo. The press release highlights some of the potential applications for this technology. I'm looking forward to seeing more studies in this area and how this technology could be utilized to develop new treatments.