Recent content by mktsgm

Thanks. But my question is about the insulin secretion in response to the gluconeogenesis. How insulin response would be different for instance from dietary glucose? Obviously GLP-1 would be missing. Something like that.

Cortisol normally initiates gluconeogenesis especially in the mornings, 1. Glucose rises due to liver gluconeogenesis. 2. Does insulin production respond to this glucose rise? 3. If it entails insulin production (due to rise in glucose), liver might store it back as glycogen leading to a futile...

Protein as it is building up in the ribosomes, amino acid sequence plays a role in determining its shape. Even here, as Philip Koeck pointed out, some other factor has a role in its misfolding (in spite of the same amino acid sequence). I too wanted to know, what is that "some other factor?"...

What determines protein/biomolecule folding or why it folds in a particular way? For instance, both glucose and fructose have same molecular formula (C6H12O6) with same chemical constituents (CHO) . But glucose has its carbonyl group at the end of the carbon chain, but fructose has its carbonyl...

Precisely my question. Is it simply arithmetic only? Suppose, if 50 units of insulin is required at a particular instant for a person. If 40% insulin resistance is present, we may need to replenish with extra 20 units of insulin. But again this extra 20 units also would undergo 40% resistance...

Thank you for the response. It discusses the pathophysiology and mechanism, but I am afraid they don't answer my questions. Hyperinsulinemia is normal in type-2 diabetes condition, especially in the early periods. I understand that both hyperinsulinemia and hyperglycemia can exist at the same...

In your 2 diabetes insulin secretion is present, but it is ineffective. It means that the circulating insulin is unable to push all the glucose into cells. They call it insulin resistance. But at the same time, if synthetic insulin is injected or insulin-secreting drugs are given, they seem to...

I was confused when I read wikipedia article on ATP Hydrolysis. ATP hydrolysis is the catabolic reaction process by which chemical energy that has been stored in the high-energy phosphoanhydride bonds in adenosine triphosphate (ATP) is released after splitting these bonds, for example in...

With due respects... no. What determines a process or part of process endergonic or exergonic? And how and why chemistry and biology differs. This is what I wanted to know. Thanks.

Generally it is said that all biological catabolic reactions are exergonic. Famous example is ATP hydrolysis is exergonic. That's why it is called energy currency. Similarly breaking of glucose molecule into pyruvate also releases energy to form ATP. But in chemistry it is said that breaking of...

Thanks for the referral. I am quite familiar with the pancreas function. And just now, while searching for answers to my question, I came across this link. Anomeric Nature of Glucose and Its Implications Perhaps this paper is nearly discussing something similar to my doubt "Anomeric Nature of...

I have a doubt about the process of type-2 diabetes. It is said that insulin resistance leads to type-2 diabetes. That would mean, even in the presence of insulin, the glucose uptake into the cells does not take place, leading to hyperglycemia. My doubt is, how could this happen in spite of...

Insulin's role in glucose metabolism by translocating GLUT-4 proteins into the plasma membrane (thereby regulating the uptake of glucose), in the adipose and skeletal muscle cells, is rather well known. And in the liver, insulin aids to regulate gluconeogenesis and promoting glycogen synthesis...

Type-2 diabetes patients generally display higher levels of glucose circulating in their blood. While type-1 is considered a lack of insulin disease, in type-2 it is considered that insulin may be present, but it is not working properly. It is called Insulin-resistance. Most of the drugs for...

By fatigue, I mean the feeling of loss of energy. Since ATP is the currency of energy, low ATP levels may be the underlying reason for fatigue. Normally, as in a chronic fatigue syndrome, mitochondrial dysfunction may be suspected. After going through a lot of NCBI articles on fatigue, I...